It's always surprised me that when you click on Tools>Instrument Manager - there was a delay before the instrument manager came up - not a long delay, but given I am using only solid state drives (and a tonne of RAM, Xeon CPU with hyperthreading) I knew it was software related - so interestingly moving to the 64-bit variant improves operational speed with the instrument manager being displayed immediately (ie no delay)
I would be curious to hear other users experiences